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ClC 6 H 4 CHO + H 2 C( CN) 2 → ClC 6 H 4 CHC( CN) 2 + H 2 O. The reaction is catalysed with weak base like piperidine or pyridine. The production method has not changed since the substance was discovered by Corson and Stoughton.
Other bases, solvent free methods and microwave promotion have been suggested to improve the production of the substance. The physiological properties had been. MSDN Magazine Issues and Downloads. Read the magazine online, download a formatted digital version of each issue, or grab sample code and apps.